This perspective piece reviews new omics, developmental genetic, and cell lineage studies to critically review current models of developing forebrain organization. Spoiler: there are _serious_ problems with the prosomere model.
Seth Blackshaw
Well done to @elsieplace.bsky.social, Marysia Placzek and @sethblackshaw.bsky.social for this beautifully clear overview of a very complex history of brain developmental models
www.sciencedirect.com/science/arti...
Proud to have been part of this work.
Excited to finally share the final/final.doc version of our paper. It's been a journey, but very proud of the result. Well done to all involved, especially @elsieplace.bsky.social
@kchinnaiya.bsky.social , @thomasdwkim.bsky.social, @sethblackshaw.bsky.social 👏👏
www.nature.com/articles/s41...
For over three decades, the prosomere model has influenced our understanding of vertebrate brain development by proposing that the forebrain consists …
Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...
Second paper is a collaboration with Jim Handa's lab at Hopkins. Cigarette smoke exposure induces aging-related molecular changes in both mouse and human retinal pigment epithelium.
www.pnas.org/doi/10.1073/...
Seth Blackshaw
Seth Blackshaw
Happy to announce that our latest paper is now out! Have you ever wondered how neural tissues control their size? In this paper, we show that cell division orientation is critical in both the cortex and retina. www.science.org/doi/10.1126/...
Michel Cayouette
www.pnas.org
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
"Choose your training environment carefully. Lab culture and institutional culture will significantly impact your happiness and success, so choose carefully." - OneNeuro Profile: Seth Blackshaw, PhD @sethblackshaw.bsky.social www.oneneurojhu.org/2026/01/29/o...
OneNeuro Initiative
I'm excited to share our PNAS paper from 1st author Kasia Hussey. We study how the foveola, the high acuity region of the retina, is patterned by RA and TH. We were surprised to find that cone subtypes appear to convert fates. Our studies are important for AMD sufferers. www.pnas.org/doi/10.1073/...
In the central region of the human retina, the high-acuity foveola is notable for
its dense packing of green (M) and red (L) cones and absence of b...
