Our latest: Minimal essential requirements for neural tube self-organisation
How does a single cell give rise to a tissue with the right cell types in the right proportions?
We deconstruct and rebuild a self-organising tissue from first principles
A thread🧵
www.biorxiv.org/content/10.6...
Wound repair is more than simply closing a gap in the tissue. Mechanical injury rapidly reshapes signaling, nuclear organization, and cellular identity across the epithelium. I'm @johanajnabi.com, and here are studies that changed how I think about epithelial wound healing.
bsky.app/profile/epim...
Hundreds of organelles. Disorder → order. No blueprint.
The switch? Actin crosslinking. The moment the meshwork forms, Basal Body dynamics shift from diffusive to subdiffusive. Same transition. Same developmental window - Every time.
New preprint from my postdoc. Full thread👇
Video
We are excited to announce another new webinar series, this time on cell migration, hosted by @pjsaez.bsky.social & @valeriaventurini.bsky.social. In our 1st webinar, we’ll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social.
🗓️11 June, 15:00 BST
Very excited to be sharing our new paper, just out in Nature Cell Biology!
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...
How does a relatively simple tube become a complex brain? 🧠
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. 🧵
New preprint from my postdoc at @nerurkar.bsky.social lab:
doi.org/10.64898/202...
💥 🚀 New preprint! 🎉🥳
How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪
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