Doing #EpithelialMechanics! with chick embryo ๐ฃ
Convenor @epimechfc.bsky.social // Postdoc @NerurkarLab at Columbia // PhD @xaviertrepat.bsky.social lab at IBEC Barcelona
jexpnimesh.com
Nimesh Chahare
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We are excited to announce another new webinar series, this time on cell migration, hosted by @pjsaez.bsky.social & @valeriaventurini.bsky.social. In our 1st webinar, weโll hear talks from @juanmagararc.bsky.social, @kyohalie.bsky.social & @djcohen.bsky.social.
๐๏ธ11 June, 15:00 BST
How does a relatively simple tube become a complex brain? ๐ง
One of the most dramatic transformations in development!
We built a framework to map exactly what changes. ๐งต
New preprint from my postdoc at @nerurkar.bsky.social lab:
doi.org/10.64898/202...
Our latest: Minimal essential requirements for neural tube self-organisation
How does a single cell give rise to a tissue with the right cell types in the right proportions?
We deconstruct and rebuild a self-organising tissue from first principles
A thread๐งต
www.biorxiv.org/content/10.6...
Hundreds of organelles. Disorder โ order. No blueprint.
The switch? Actin crosslinking. The moment the meshwork forms, Basal Body dynamics shift from diffusive to subdiffusive. Same transition. Same developmental window - Every time.
New preprint from my postdoc. Full thread๐
Very excited to be sharing our new paper, just out in Nature Cell Biology!
The big question we investigate: How do migrating cells put their front ๐ด and back ๐ต in the right place?
Wound repair is more than simply closing a gap in the tissue. Mechanical injury rapidly reshapes signaling, nuclear organization, and cellular identity across the epithelium. I'm @johanajnabi.com, and here are studies that changed how I think about epithelial wound healing.
bsky.app/profile/epim...
The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...
๐ฅ ๐ New preprint! ๐๐ฅณ
How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order ๐ช
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