🔬🦠 Comment #Klebsiella parvient-elle à changer de capsule aussi fréquemment pour mieux s’adapter à son environnement ?
Les travaux de @julielebris.bsky.social mis à la une par @cnrsbiologie.bsky.social 👏
-avec @epcrocha.bsky.social
#MicroSky @cbitoulouse.bsky.social
#ResultatScientifique🔎| Une bactérie capable de changer de « bouclier » pour mieux s’adapter à son environnement : une stratégie étonnante de Klebsiella pneumoniae qui éclaire ses capacités d’évolution et de résistance.
✍️ @olayarendueles.bsky.social @julielebris.bsky.social
▶️ buff.ly/q8AKHo1
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @julielebris.bsky.social @olayarendueles.bsky.social &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @plosbiology.org 🧪 plos.io/4s64Ko0
A new era of bacteriophage research is underway. microLife’s thematic issue on Viruses of Microbes brings together studies exploring bacterial immunity, the role of phages in microbiomes, & their growing use in molecular biology & next-gen phage therapy. Explore the thematic issue: buff.ly/f8rLFus
TraF from a broad-host monoderm plasmid is the first conjugative T4SS component with strong homology to T7SS pseudokinase 🧬 Grohmann & Keller labs elucidate its crystal structure, function and partners. @uni-grat.at & BHT_berliner
👉️ buff.ly/ndoiPD4
What happens when Klebsiella's capsule locus is swapped? Unexpectedly little in terms of cell growth. Yet, it does change the bacterium's environment and interactions with it: evolution by seamless plug-and-play capsule swap. Led by @julielebris.bsky.social @olayarendueles.bsky.social
🌟 Very proud of the newest Dr. in the team ,
Dr. @julielebris.bsky.social 👩🎓!
She brilliantly defended her PhD last Friday @pasteur.fr
Excellent thesis in terms of output & quality!
Thanks to the jury @lucyweinert.bsky.social @sylvainbrisse.bsky.social @edfeil.bsky.social Maria Halima Laaberki
Our latest manuscript explores capsule exchangeability & phenotypic portability
We didn’t directly address its role in #virulence
⏩️ that was already elegantly shown here—worth a look 👀👇🏻
doi.org/10.1371/jour...
🎯 Their results supports our plug-and-play model!
Bonus: we kept 🐭 alive
#microsky
Fluorescent labeling extended to 3 streptococcal species 🧫✨ @veeninglab.com & coll. benchmarked 5 proteins and developed multicolor cassettes enabling triple labeling—expanding tools for gene expression, cell dynamics & infection studies.
👉️ buff.ly/DFMXjE7
So happy to see this finally published in @plosbiology.org!
This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!
#ResultatScientifique🔎| Une bactérie capable de changer de « bouclier » pour mieux s’adapter à son environnement : une stratégie étonnante de Klebsiella pneumoniae qui éclaire ses capacités d’évolution et de résistance.
✍️ @olayarendueles.bsky.social @julielebris.bsky.social
▶️ buff.ly/q8AKHo1
CNRS Biologie
Eduardo Rocha
Olaya Rendueles
PLOS Biology
Olaya Rendueles
So happy to see this finally published in @plosbiology.org!
This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!
Author summary Klebsiella pneumoniae is a major human pathogen. While capsule is the main virulence factor of the pathogen, only several of more than 80 capsule serotypes are frequently identified in ...
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @julielebris.bsky.social @olayarendueles.bsky.social &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @plosbiology.org 🧪 plos.io/4s64Ko0
PLOS Biology
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
www.biorxiv.org
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
