#ResultatScientifique🔎| Une bactérie capable de changer de « bouclier » pour mieux s’adapter à son environnement : une stratégie étonnante de Klebsiella pneumoniae qui éclaire ses capacités d’évolution et de résistance.
✍️ @olayarendueles.bsky.social @julielebris.bsky.social
▶️ buff.ly/q8AKHo1
TraF from a broad-host monoderm plasmid is the first conjugative T4SS component with strong homology to T7SS pseudokinase 🧬 Grohmann & Keller labs elucidate its crystal structure, function and partners. @uni-grat.at & BHT_berliner
👉️ buff.ly/ndoiPD4
A new era of bacteriophage research is underway. microLife’s thematic issue on Viruses of Microbes brings together studies exploring bacterial immunity, the role of phages in microbiomes, & their growing use in molecular biology & next-gen phage therapy. Explore the thematic issue: buff.ly/f8rLFus
What happens when Klebsiella's capsule locus is swapped? Unexpectedly little in terms of cell growth. Yet, it does change the bacterium's environment and interactions with it: evolution by seamless plug-and-play capsule swap. Led by @julielebris.bsky.social @olayarendueles.bsky.social
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @julielebris.bsky.social @olayarendueles.bsky.social &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @plosbiology.org 🧪 plos.io/4s64Ko0
Fluorescent labeling extended to 3 streptococcal species 🧫✨ @veeninglab.com & coll. benchmarked 5 proteins and developed multicolor cassettes enabling triple labeling—expanding tools for gene expression, cell dynamics & infection studies.
👉️ buff.ly/DFMXjE7
🌟 Very proud of the newest Dr. in the team ,
Dr. @julielebris.bsky.social 👩🎓!
She brilliantly defended her PhD last Friday @pasteur.fr
Excellent thesis in terms of output & quality!
Thanks to the jury @lucyweinert.bsky.social @sylvainbrisse.bsky.social @edfeil.bsky.social Maria Halima Laaberki
Our latest manuscript explores capsule exchangeability & phenotypic portability
We didn’t directly address its role in #virulence
⏩️ that was already elegantly shown here—worth a look 👀👇🏻
doi.org/10.1371/jour...
🎯 Their results supports our plug-and-play model!
Bonus: we kept 🐭 alive
#microsky
So happy to see this finally published in @plosbiology.org!
This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!
🔬🦠 Comment #Klebsiella parvient-elle à changer de capsule aussi fréquemment pour mieux s’adapter à son environnement ?
Les travaux de @julielebris.bsky.social mis à la une par @cnrsbiologie.bsky.social 👏
-avec @epcrocha.bsky.social
#MicroSky @cbitoulouse.bsky.social
CNRS Biologie
FEMS Journals
FEMS Journals
PLOS Biology
FEMS Journals
Eduardo Rocha
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
So happy to see this finally published in @plosbiology.org!
This is the first chapter of @julielebris.bsky.social PhD thesis demonstrating how capsules are exchanged by plug-and-play dynamics
w/ @epcrocha.bsky.social
#microsky @klebclub.bsky.social
Link below-
Check out her 🧵 for more details!
#ResultatScientifique🔎| Une bactérie capable de changer de « bouclier » pour mieux s’adapter à son environnement : une stratégie étonnante de Klebsiella pneumoniae qui éclaire ses capacités d’évolution et de résistance.
✍️ @olayarendueles.bsky.social @julielebris.bsky.social
▶️ buff.ly/q8AKHo1
Author summary Klebsiella pneumoniae is a major human pathogen. While capsule is the main virulence factor of the pathogen, only several of more than 80 capsule serotypes are frequently identified in ...
doi.org
Olaya Rendueles
How complex multi-gene systems evolve across genetic backgrounds without disruptive epistasis remains unclear, particularly in highly exchangeable loci such as the capsule of Klebsiella pneumoniae. Th...
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
How do multi-gene systems evolve across genetic backgrounds without disruptive epistasis? @julielebris.bsky.social @olayarendueles.bsky.social &co show the #Klebsiella capsule locus is a plug&play module that swaps with low fitness cost while preserving #virulence @plosbiology.org 🧪 plos.io/4s64Ko0
Julie Le Bris
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
