We've been investing heavily in better protein language models (PLMs), but relatively little work addresses how to best generate with them. We present a new search-based method for PLMs and exhaustively benchmark models and methods, including with in vitro data from antibody therapeutics campaigns.🧵
New preprint from the group!
Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @prbb.org @grib-barcelona.bsky.social
www.biorxiv.org/content/10.6...
With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.