We are mononuclear phagocytes enthusiasts and we organise biennial international meetings on the topic in France...
https://www.cfcd.fr
The French DC Society - Club Francophone des DC (CFCD)
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🚨 We are pleased to announce that we have an open call for travel grants for conferences in the field of dendritic cells. Do not hesitate to apply 🚨
More details 👇
The French DC Society - Club Francophone des DC (CFCD)
The laboratory of @laouimmunology.bsky.social provides in @natcomms.nature.com "an in-depth characterization of the tumor-associated dendritic cell compartment in mouse and human cancers" 👇
www.nature.com/articles/s41...
Another paper out this week in @scienceimmuno.bsky.social by the Reizis laboratory showing that "Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells" Congrats 👏https://www.science.org/doi/10.1126/sciimmunol.adx4622
Congrats to the Reizis lab for this beautiful paper in @science.org identifying the "transcription factor Etv3 as controling the tolerogenic function of dendritic cells"
www.science.org/doi/10.1126/...
@reisesousalab.bsky.social et al. show in @natcancer.nature.com that "non-specialized APCs such as cDC2 and moDCs can be harnessed for cross-presentation of necrotic tumor antigens through F-actin-Fcγ receptors bridging".
www.nature.com/articles/s43...
Very cool paper in @cp-immunity.bsky.social showing that a "dietary modulation of NKT-XCL1-cDC1 axis in combination with immune check points inhibitors may open avenues for improved treatments of colon cancer".👇
www.sciencedirect.com/science/arti...
Congrats to the @sancholab.bsky.social et al, for this nice paper in @natcomms.nature.com showing that "type 1 conventional dendritic cell-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
Fresh from science immunology, the @sancholab.bsky.social group identifies " the mitochondrial redox metabolism as a key regulator of antigen cross-presentation in conventional type 1 DCs" 👏 and 👇
www.science.org/doi/10.1126/...
Congrats to Mei Li and team for this nice story in @natimmunol.nature.com showing "that TSLP from keratinocytes activates transitional DC-derived DC2 to promote GATA3+ regulatory T cells and mediate immunosuppression during inflammation and cancer".
www.nature.com/articles/s41...
Online now: Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
www.nature.com
Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
Immunity
Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.
www.science.org
Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...
Multiple lineages and functional states of tumor-associated dendritic cells (TADCs), as essential inducers of anti-tumor immunity, have been reported. Here, the authors have generated single-cell RNA ...
Recent work has revealed that dendritic cells (DCs) are more heterogeneous than previously thought, yet the functional roles of these newly described DC subsets remain unclear. Here, Li et al. find th...
Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...
www.nature.com
The efficacy of immune checkpoint inhibitors (ICIs) in colon cancer (CC) is limited by the tolerogenic immune landscape of both the tumor and the inte…
Specialized fibroblastic reticular cell (FRC) subsets in lymph nodes orchestrate the compartmentalization that guides immune cell migration, interaction, and function. Alouche et al. examine the signals governing FRC differentiation and identify a Notch2-dependent process by which homeostatic mature dendritic cells drive Ccl19hi T-zone fibroblast differentiation, maintain segregation of distinct T-zone niches, and support CD8+ T cell memory formation.
