Assistant Professor @OhioState in a toxic relationship with lysosomes. ECR Editor @MBoCjournal. Former @NIH. Views are my own. http://bonetponcelab.com/
Luis Bonet-Ponce
'Endosomal-lysosomal network dysfunction in neurodegeneration'. 13 speaker slots for selected posters. Session chair slots. Keynotes, Frances Platt + Volker Haucke. Colworth Medal Ben Ryskeldi-Falcon. Discussion panels + more. SUPER EARLY DEADLINE 1st JUNE 2026. www.eventsforce.net/biochemsoc/f...
New paper, new tool! šØ Where a signaling protein lives matters as much as what it does. Our new tool lets you interrogate this one compartment at a time. We built TerminaTOR, a genetically encodable inhibitor that silences mTORC1 at subcellular locations.
'Endosomal-lysosomal network dysfunction in neurodegeneration'. 13 speaker slots for selected posters. Session chair slots. Keynotes, Frances Platt + Volker Haucke. Colworth Medal Ben Ryskeldi-Falcon. Discussion panels + more. SUPER EARLY DEADLINE 1st JUNE 2026 www.eventsforce.net/biochemsoc/f...
Jin Zhang Lab
Peter Cullen
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social.
Available now on BioRxiv: doi.org/10.64898/202...
Glad to share our new @cp-trendscellbio.bsky.social article! We discuss how repair condensates and lipid domains work together to restore lysosome integrity or deciding if it's time for lysophagy.Ā #Lysosomes #Condensates #DamageSignature #Lipids #Ions Check it out: doi.org/10.1016/j.tc...
š„Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al!
link.springer.com/article/10.1...
On behalf of #TeamTansey we will investigate the role of #immuneaging in the heterogeneity of #Parkinsons and look forward ending #Parkinsons at Indiana University School of Medicine #Neurology & Stark Neurosciences Research Institute with the continued support of ASAP & MJFF lnkd.in/gzRbb95R
Fantastic work by Aakriti Jain @aakritijain.bsky.social in team
with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical
for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!
www.eventsforce.net
Luis Bonet-Ponce
Peter Cullen
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations š§µš
doi.org/10.64898/202...
Carter Lab
doi.org
Claudio Bussi
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations š§µš
doi.org/10.64898/202...
doi.org
Roberto Zoncu Lab
Max Gutierrez
Prof MalĆŗ GĆ”mez Tansey
doi.org
rdcu.be
Ennio
Ennio
www.eventsforce.net
This link will take you to a page thatās not on LinkedIn
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids š§¬ [1/6]
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...
š¢ Unraveling Parkinsonās. Advancing Precision Medicine.
New CRN grants in partnership with The Michael J. Fox Foundation for Parkinsonās Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery.
š Learn more: bit.ly/4ugkfes
