Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology. Lipid droplets, ferroptosis, ubiquitin, drug development.
James Olzmann
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Also exciting to see a complementary study from @angelifriedmann.bsky.social @veraskafar.bsky.social & colleagues published in Nature Cell Biol today. Together, our studies highlight a role for vitamin B2 metabolism and FAD in regulating FSP1 and ferroptosis.
www.nature.com/articles/s41...
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Huge congratulations to the entire team for driving this project forward. Grateful for fantastic collaborators, including @theprattgroup.bsky.social and everyone in the lab who contributed to this work.
A true team effort across genetics, cell biology, and chemical biology.
#Vitamin B2 is converted into molecules which protect cells from oxidative damage. The downside: It also protects #cancer cells. Scientists at the Rudolf Virchow Centre at #JMU discovered that. 📸 Natalie Fahmer
➡️ www.uni-wuerzburg.de/en/news-and-...
New online: FAD-dependent stabilization of FSP1 promotes ferroptosis resistance
1/3 Thrilled to see our paper led by Kirandeep Deol is out in Nature Structural & Molecular Biology! CRISPR screens to uncover a role for vitamin B2 metabolism in stabilizing FSP1 via FAD, revealing a new way vitamins regulate ferroptosis.
www.nature.com/articles/s41...
Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand.
www.nature.com/articles/s41...
California Bill Would Create A $23 Billion Fund For University Research
Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out
thttps://www.nature.com/articles/s41556-025-01856-x
Cool paper alert 🚨! Congrats @olzmannlab.bsky.social!
Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️
James Olzmann
CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly by promoting membrane bending and fusi...
Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org
A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.
