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Cell death and immune responses are linked all across the tree of life. But they interact in funny and opposing ways depending on the species "FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster" link.springer.com/article/10.1...
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STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterize...
FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster - The EMBO Journal
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Cristina Muñoz Pinedo