Plus, FGF signaling activates expression of APOD, building a positive feedback loop! This means that FGFs ensure their robust signaling by recruiting APOD-dependent lipid management. Without this feedback, inner ear development fails.
We asked how tissues reliably read morphogen signals to make precise fate decisions. This led us to find the secreted lipid chaperone APOD amplifies FGF/MAPK to drive the development of the otic placode, the precursor to the inner ear.
We're #hiring! Our group in the Cell Bio Dept at Hopkins is looking for a Research Technologist to join us and study #neuralcrest #cellmigration during #devbiol! Looking to build up your lab experience? Check it out! @socdevbio.bsky.social @ascbiology.bsky.social
jobs.jhu.edu/job/Baltimor...
Since APOD binds membrane lipids to regulate their organization, peroxidation, and metabolism, this reveals that lipid management is an important regulatory layer that tunes receptor signaling during early embryonic development!
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
Looking forward to it!
Uh oh what did I do? But yes please, we should make this happen - there or before?
I'm so excited for #ICDB2025, it's looking like such a great meeting and I'm honored to share our work!
Thank you, Rohan!
Totally BOSS move: Harvard completely redid its home page to push back on the threats to research. 12/10 no notes www.harvard.edu