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#StructuralBiology insights into #Genetic #GPCR variations identified in the UK 100,000 Genomes Project with differentiating effects on peptide (affected) vs. small molecule agonists (not affected) #pharmacology www.nature.com/articles/s41...
Jan 10, 2025
This study explores apelin receptor’s role in cardiovascular function, identifying residues critical for binding through genetic variants, AlphaFold2 modelling and base editing in cardiomyocytes. Co-c...
Structural and functional determination of peptide versus small molecule ligand binding at the apelin receptor - Nature Communications
www.nature.com
Chris de Graaf