#StructuralBiology insights into #Genetic #GPCR variations identified in the UK 100,000 Genomes Project with differentiating effects on peptide (affected) vs. small molecule agonists (not affected) #pharmacology
www.nature.com/articles/s41...
@baoilleach.bsky.social on #Bluesky!
@baoilleach.bsky.social on #Bluesky!
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Analysis of the oldest-known genomes from early modern humans in Europe, who lived around 45,000 years ago, helps to provide a more precise date for when Neanderthals and modern humans mixed, according to research published in Nature. https://go.nature.com/3ZR8Kh1 🧪 🏺
Closing the loop on #GenAI for #GPCR #SBDD
www.nature.com/articles/s41...
tinyurl.com/yeyhfr7j
Closing the loop on #GenAI for #GPCR #SBDD
www.nature.com/articles/s41...
tinyurl.com/yeyhfr7j
Protein backbone diffusion models consistently undersample catalytically important motifs, and oversample idealized helices, raising questions about the appropriateness of these methods in designing starting points for enzyme design & evolution. From www.biorxiv.org/content/10.1...
If you are interested in #AI and #DrugDiscovery, attend the upcoming ICCS June 1st - Jun 5th in Noordwijkerhout!
Last call for papers. Please repost!
Registration and abstracts (deadline 14 Feb): iccs-nl.org/general-info...
ChEMBL 35 is out. Happy Holidays!
chembl.blogspot.com/2024/12/here...