Evolution of developmental mechanisms, especially axial patterning. Experimental embryology. 🪸🪼
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For decades, cellular aggregation was considered an evolutionary dead end.
Cells could come together temporarily.
But complex multicellular organisms like animals?
Our study, led by JP Gerdt, with Ruibao & @jennahed.bsky.social suggests it may be time to rethink that🧵 #ProtistsOnSKy
Video
Excited to see this work from June Ordoñez's PhD published in Frontiers in Cell and Developmental Biology! 🎉
www.frontiersin.org/journals/cel...
#zoology #spiralia #development #evolution
Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling
Iñaki Ruiz-Trillo
🐭 Female mice develop male genitals when researchers modified both copies of non-coding Enh13, which controls Sox9 gene responsible for testes development in male mice. This suggests Enh13 acts as an enhancer and a silencer of Sox9, per Nature Communications study.
#SciSky #MedSky 🧪
Computational assessment identifies probe binding errors in a widely used commercial platform for spatial transcriptomics.
