The locus coeruleus, which provides norepinephrine to the rest of the brain, is even more spatially and functionally diverse than previously thought, new findings suggest.
By Holly Barker
www.thetransmitter.org/locus-coerul...
The arrangement of locus coeruleus neurons in mice points to how the structure mediates specific effects across the brain, a new study shows.
1/ New preprint from our lab:
“Locus coeruleus activation transforms cortical taste representations”
We asked how a major neuromodulatory system reshapes cortical taste coding toward behaviorally meaningful features.
www.biorxiv.org/content/10.6...
🧠 New paper out in 𝘉𝘳𝘢𝘪𝘯
Why does tau pathology often begin in the entorhinal cortex in Alzheimer’s disease?
We show that brain-wide gradients of neuronal activity and amyloid-β may make this region particularly vulnerable to tau pathology.
academic.oup.com/brain/articl...
www.biorxiv.org
I am recruiting an exceptional postdoc to join my lab at UC Irvine. Must be a productive researcher with experience in functional neuroimaging, network neuroscience, AI/ML, who is interested in aging, neuropsychiatric or neurodegenerative illness.
www.linkedin.com/jobs/view/44...
Recent studies have revealed the synchronization of neuromodulators including norepinephrine, serotonin, acetylcholine, dopamine, and histamine during sleep.
A new #ScienceReview explores what potential role the synchronization of these oscillations may play in health. https://scim.ag/3PEGdsW
Christoffer G. Alexandersen
I'll be presenting two posters at OHBM this week - come say hi!
[0510] Spatial collinearity constrains multivariate molecular
enriched network estimation
↳ Monday & Tuesday
[1985] Locus Coeruleus Connectivity Confers Cognitive
Resilience in Preclinical Alzheimer’s Disease
↳ Wednesday & Thursday
Natale R. Sciolino, PhD
Here's a bit of unusual work on error processing and error awareness from our lab, which we've been working on off and on for around eight years: www.biologicalpsychiatrycnni.org/article/S245...
Details in thread
Postdoc opportunity to investigate the role of noradrenaline in Alzheimer's disease. Require: strong fMRI (fMRS) skills and interest in predictive coding. The Martinos Center in Boston is a superb place to work. Reach out for info; I will be in London (AAIC) and NL in July shorturl.at/1HSey
Posted 12:31:04 AM. Postdoctoral Fellow – Neuroimaging, Network Neuroscience & AI/ML in Cognitive DisordersYassa Lab |…See this and similar jobs on LinkedIn.
www.linkedin.com
Dual orexin receptor antagonism with lemborexant enhances #microglial clearance of β-#amyloid in mice
Ashish Sharma, Emiko Segawa, Xiaoying Chen...Erik S. Musiek @washumedicine.bsky.social #Sleep #AlzheimersDisease
link.springer.com/article/10.1...
During wakefulness, neuromodulators operate largely independently to support behavior and cognition. By contrast, sleep reorganizes their activity into a coordinated brain rhythm. During sleep, the ma...
Postdoctoral opportunity to work on understanding the role of the noradrenergic system in Alzheimer's disease pathophysiology and symptoms. The focus is on integrating 3T and 7T MRI (sMRI, fMRI, MRS)...
Conscious error detection is accompanied by error-related changes in phasic autonomic
activity. This autonomic response is diminished in older age – accompanied by impairments
in the conscious detecti...
