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Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity: Cell Chemical Biology www.cell.com/cell-chemica...
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Hao et al. report the cryo-EM structure of the human CbA–Sec61 complex to develop photo-controlled and hypoxia-activated prodrugs. This backbone-engineering strategy overcomes the on-target toxicity o...
Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity
Eric Chevet