Hey y'all, let's make Thermo Fisher and their "optimization" famous🧪
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times.
www.thermofisher.com/us/en/home/l...
Scientific Streisand Effect
Fantastic !!
Structure-based design of Sec61 translocon targeting prodrugs minimize off-target toxicity: Cell Chemical Biology www.cell.com/cell-chemica...
Violence on the streets of the U.K. incited and enabled by Elon Musk, a fellow of the @royalsociety.org. When will our national academy stand up for the values it claims to espouse?
Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now! diabetesjournals.org/care/article...
Good morning! This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: Prevalent gut phages encode modular adhesins mediating epithelial binding and endoplasmic reticulum trafficking www.nature.com/articles/s41...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Hao et al. report the cryo-EM structure of the human CbA–Sec61 complex to develop
photo-controlled and hypoxia-activated prodrugs. This backbone-engineering strategy
overcomes the on-target toxicity o...
Hao et al. report the cryo-EM structure of the human CbA–Sec61 complex to develop photo-controlled and hypoxia-activated prodrugs. This backbone-engineering strategy overcomes the on-target toxicity of Sec61 inhibition by restricting activity to tumor microenvironments, demonstrating potent anti-tumor efficacy in a colon cancer CDX model.
The opinions expressed in this editorial are the personal views of the authors (S.E. Kahn, C.A.M. Anderson, J.B. Buse, and E. Selvin) and do not represent
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times.
www.thermofisher.com/us/en/home/l...
How do cells control formation of Golgi stacks upon demand?
Roman Polishchuk, Franck Perez and collaborators identify a ‘Golgi regulon’ under control of the CREB3L1 transcription factor
link.springer.com/article/10.1...
Christine Mayr
If the goal was to not let them share reprints of an editorial, maybe having the police escort them out was not the best choice 😭😭 @altmetric.com
www.altmetric.com/details/1954...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
This is a pogrom, incited and instigated by Elon Musk.
This is now the second set of pogroms incited by Elon in the UK in 2 years.
Video
The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Video
The criticism of Trump, Kennedy, and Bhattacharya that was so subversive that the ADA had to eject the Editor-in-Chief of their flagship journal from their annual meeting for sharing it? Prior today it had fewer than 1000 views.
Do your thing.
My colleague @hannahalothman.bsky.social is in Belfast tonight. This is what she’s seen.
www.theguardian.com/politics/liv...
