"Hundreds of scientists who study cancer and aging have made an easily avoidable but significant mistake, deploying the wrong antibody to test for a key protein..." By Mitch Leslie @science.org; originally reported by Sholto David
www.science.org/content/arti...
Dorian McILROY
Paul Offit
Cancer and cell aging studies may have relied on antibodies to incorrect molecule
Transferrin receptor 1 binds human parvovirus B19 VP1u to facilitate entry
www.nature.com/articles/s41...
One massive hurdle in fighting Ebola in DRC: Ituri has nowhere near the capacity it needs for safe and dignified burials, just 7 of 98 needed ambulances, for instance.
That means higher likelihood of unsafe burials and new infections as well as longer wait and more anger/mistrust in communities.
ASV is alarmed by the US HHS to suspend and debar Dr. Ralph Baric from federal funding. Read our open letter below:
Another fantastic preprint on BA.3.2's propensity for children, this time from Yunlong Cao & co.
They not only confirm David Ho's lab findings (that kids have ~0 Ab response to BA.3.2) but dig into the details of exactly why kids are so vulnerable to BA.3.2.
www.biorxiv.org/content/10.6...
1/6
The basis for the last sentence below: New data from David Ho's lab showing that while adults & kids have ~equal antibody responses to XFG & NB.1.8.1, children have essentially no neutralizing antibodies to BA.3.2.
This seems to solve the BA.3.2 + kids mystery. 1/14
www.biorxiv.org/content/10.6...
My new piece looks at recent bizarre overestimates of Long COVID rates.
Also, how we can be fairly certain that the true rate of Long COVID is now very low in 2026.
open.substack.com/pub/gidmk/p/...
Researchers identify transferrin receptor 1 as the long-sought receptor, previously termed VP1uR, required for parvovirus B19 entry into erythroid cells, and determine the cryo-EM structure of the rec...
The ongoing evolution of SARS-CoV-2 is heavily constrained by population-level immune imprinting. Recent genomic surveillance reveals an unexpected demographic shift: the highly mutated BA.3.2.2 subli...
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein www.cell.com/immunity/ful...
Ebola virus, a member of the Filoviridae family, causes severe disease in humans.
Gilchuk et al. isolated and characterized broadly neutralizing human monoclonal antibodies
active against all three cl...
My best guess is dead-end virus evolution combined with a continually broadening global population antibody response that makes it more difficult for novel variants to completely escape—except in those with few exposures (such as children).
