Member, Memorial Sloan Kettering Cancer Center
Co-Director, Olayan Center for Cancer Vaccines
Comp Immuno-oncology
Self/nonself theory
Co-Founder Rome Therapeutics
Physicist
Benjamin D. Greenbaum
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Sharing a paper below in Cell Genomics @cellpress.bsky.social
that took us literally 10 years+ (!) to write on the topics of:
It also required an amazing set of deep collaborations: particularly @daniel-decarvalho.bsky.social
(whose work motivated a lot of our thinking) and John Lacava who went all in for this work with their great labs and colleagues.
* How, exactly, do we quantify viral mimicry: the expression of features associated with "nonself "viruses by our own "self" cells?
* Why do we see mimicry in so many disease settings such as cancer?
* How broad a phenomena is this?
* How do we think about selection in this evolutionary context?
I would usually write a summary but I will defer to the text this time and just express thanks for the interactions and experiences this work generated. Its been a gateway into a lot of fun science that we are still unpacking...
Trying to answer these questions required a theoretical framework at the intersection of physics, machine learning and evolutionary dynamics that our lab most enjoys - led by Petr Šulc, long-time collaborators at Ecole Normale in Paris, and our amazing lab at @mskcancercenter.bsky.social
Thank you @mskcancercenter.bsky.social for highlighting our work on #viralmimicry in our genome, its evolution, the selective forces on it, and its potential role in cancer.
A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!
Nice to see this story out! The idea that viral mimicry is an intrinsic feedback mechanism for sensing cellular dysregulation is fascinating and this paper explores this idea really well.
It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
Excited to have this paper out today!
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."
It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!
www.cell.com/cell-genomic...
The first is from former PhD student Zhiru Liu @zzzhiru.bsky.social (now in @bengrbm.bsky.social's group @ MSK) examining the long-term patterns of selective constraint – measured by the classical ratio of nonsynonymous to synonymous mutations (dN/dS) – within recombining populations of bacteria.
Benjamin D. Greenbaum
Benjamin D. Greenbaum
Benjamin D. Greenbaum
Benjamin D. Greenbaum
Benjamin D. Greenbaum
Benjamin D. Greenbaum
Håvard Lindholm
Early registration rates end this coming Monday for #mDNASRC. Join your colleagues in beautiful Porto alongside organizers like @bengrbm.bsky.social. Save your space: buff.ly/P6hZjQz
