Please join us on November 20th! We are very grateful for our first sponsorship - Molecular Instrument!
Excited to see everyone tonight at Whitehead Institute for the 2nd GEARS seminar, featuring three talks from Harleen Saini, Vikram Agarwal, and Ava Carter!
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
What contributes to human specific neural specification? Check out these two wonderful preprints from a wonderful scientist Ava carter! 1. www.biorxiv.org/content/10.1...; 2. www.biorxiv.org/content/10.1...
Stay tuned! third preprint is on its way!
Join us on Wednesday next week for two exciting talks on transcription regulation from @kasitc.bsky.social and @davidsuter.bsky.social!
You can register at: us06web.zoom.us/webinar/regi...
Outstanding work from Allison James who will graduate next month! If you like our work, consider applying to the Farnung Lab. More info: farnunglab.com
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
GEARs
🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs!
🗓️ us06web.zoom.us/webinar/regi...

🧬🎉Thrilled to share our new chromatin remodeling study! We reveal three states of human CHD1 and identify a novel "anchor element" that interacts with the acidic patch—conserved among remodelers. Our structures clarify mechanisms of remodeler recruitment! Link: authors.elsevier.com/a/1l2ik3vVUP...
🌱Join us for the first #FragileNucleosome seminar of this spring! We are excited to host @juliamaristany.bsky.social & @chribue.bsky.social this week!
If you have registered before you can join from the same link, if not, don't forget to register!
us06web.zoom.us/webinar/regi...
A major challenge in human evolutionary biology is to pinpoint genetic differences that underlie human-specific traits, such as increased neuron number and differences in cognitive behaviors. We used ...
Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...
Integrator complex collapse: A mechanistic route to integrated stress response and disease
Lucas Farnung
FragileNucleosome
In a recent Cell article, Baluapuri et al. show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
