🧪 Efficient Pd/C-catalyzed hydrogenation of diene carboxylates!
A catalyst from Pd₂(dba)₃ on activated carbon (5% Pd) delivers high yields of fully saturated products, including challenging 5-membered rings.
🔗 Read more: bit.ly/4mbFnQk
#ChemSky #Catalysis #OrganicChemistry
🚀 From our #Catalysis Virtual Collection
An atom-economical, iodine-catalyzed oxidative route to olivetol, methyl olivetolate & protected derivatives from common precursors. A mild, efficient & scalable approach to valuable building blocks.
🔗 Read more: bit.ly/41ZwGzc
#ChemSky #OrganicChemistry
🧪 1,1-Dibromoolefins: versatile building blocks in synthesis!
Featuring two reactive C–Br bonds, they enable rapid access to heterocycles, functionalized olefins & alkynes from simple precursors.
📚 Explore the graphical review: bit.ly/4dU0yEk
#ChemSky #OrganicChemistry #Synthesis
💡 From our #Catalysis Virtual Collection
A metal-free iodide/peroxide strategy for direct C–H functionalization of quinoxalin-2(1H)-ones via cross-dehydrogenative coupling & arylation. Efficient access to valuable heterocycles!
🔗 Read here: bit.ly/4nvE66Z
#ChemSky #OrganicChemistry
⚗️ From our #Catalysis Virtual Collection
An aryl iodide-catalyzed oxidative strategy enables intramolecular C–N/C–O bond formation from diphenylpropanamides under mild, transition-metal-free conditions.
🔗 Read the full paper: bit.ly/3RX5qPP
#ChemSky #OrganicChemistry
🧪 Carbene or nitrene?
This graphical review explores the diverse landscape of #carbene and #nitrene precursors, highlighting their synthesis, activation strategies, reactivity profiles & key synthetic applications.
🔗 Read here: bit.ly/4x2HBpT
#ChemSky #OrganicChemistry #Synthesis
🧬 New paper on SIRT1 activators!
This study reports new 1,5-benzodiazepine-based SIRT1 activators, combining organic synthesis, #molecular docking & biological evaluation. A lead compound demonstrated promising #antidiabetic activity in vivo.
🔗 Read now: bit.ly/4xkL1EK
#ChemSky #MedicinalChemistry
⚡ From our #Catalysis Virtual Collection
An aerobic iron(III)-catalyzed direct thiolation of imidazo[1,2-a]pyridines enables regioselective access to C3-sulfenylated heterocycles under mild conditions. Efficient #synthesis with promising bioactive derivatives!
🔗 Read now: bit.ly/4eVcCpt
#ChemSky
💡 From our #Catalysis Virtual Collection
A visible-light-mediated photocatalytic oxidative cleavage of geminal diazides, using an organic dye as catalyst, enables efficient access to oxamates under mild, metal-free conditions.
🔗 Read here bit.ly/4utWTlC
#ChemSky #OrganicChemistry #Photocatalysis
Discover boron chemistry in #catalysis in our next Thieme #Cheminar with our speakers Hirohisa Ohmiya (Japan), Elena Fernández (Spain), and James Morken (USA). Chaired by Martin Oestreich.
📅 Apr 14 | 🕑 14:00 CET
👉 Sign up now to save your spot: bit.ly/4t2czfA
#ChemSky
