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Thrilled to share our latest work in @natcomms.nature.com ! MICAL1 mediates shear-dependent actin remodeling, enabling GPIb-IX-V mechanotransduction and platelet function, and reveals a previously unrecognized role for actin oxidation #mical1 #platelets #cytoskeleton #vwf #gpib
10mo
HITh lab InsermU1176
Excited to share that our paper is out in @natcomms.nature.com 🔗 rdcu.be/ez3Gt We uncover how MICAL1 regulates actin dynamics to enhance VWF–GPIbα binding in platelets. Big thanks to all co-authors & collaborators ! @hithlabinserm1176.bsky.social @echardlab-pasteur.bsky.social
10mo
Nature Communications - To stop bleeding from an injured vessel, platelets adhere and form a clot despite high shear stress from the flow. Here, the authors show that platelet actin disassembly is...
rdcu.be
F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
Alex K