Cell & developmental biologist. Exploring instructive cues encoded in cell shape â in vascular development, morphogenesis and beyond. https://herbertlab.com/ @uniofmanchester.bsky.social @fbmh-uom.bsky.social @mcf-uom.bsky.social
Shane Herbert
Cool - ever multitalented endothelial cells!
Frictiotaxis - amazing!
It's great to have media attention on our recent paper, but, some of these 'news' articles are completely wacky! đ¤Ł
Shane Herbert
I really hope I can make this - and seems crazy that this is the 1st UK meeting! Should be excellent!
Bit of a nerdy dream for our paper to be covered by @newscientist.com! And lovely kind words from @buzzbaum.bsky.social. Just a shame that the daughter cells on the cover image are round and symmetric đ¤Ł. www.newscientist.com/article/2478... www.newscientist.com/article/2478...
If youâve ever wondered how cells tune positioning of organelles in response to cell shape change, and what happens when this goes wrong, please check out our new manuscript â mRNA trafficking controls cell-size-scaled organelle dynamics! www.nature.com/articles/s41...
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that âInterphase cell morphology defines the mode, symmetry, and outcome of mitosisâ - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Shane Herbert
Shane Herbert
Looking foward to the Northern(ish) Developmental Biology Meeting 2025 next week @sheffielduni.bsky.social! Thanks to the organisers @shaneherbert.bsky.social Raman Das @tsakiridis.bsky.social @kyracampbelllab.bsky.social
Shane Herbert
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
How mitochondria positioning dynamically adapts to changes in cell shape is poorly understood. Here, Bradbury et al. show that cell-size-dependent trafficking of TRAK2 mRNA underpins the cell-size-sca...
đšKletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a determinant in #organelle size control.
bit.ly/4mhMvsU
Anzy Miller
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
Check out our new work @natcomms.nature.com! @mayorlab.bsky.social discovered that cells perform durotaxis even without focal adhesions. How? Well, we found that they actually follow friction gradients â a new mode of directed cell migration that we call frictiotaxis!
www.nature.com/articles/s41...
Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! đ Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...
Nature Cell Biology
Doug Dyer
Ricard Alert ZenĂłn
Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties of the cytoplasm are a det...
Cells typically migrate toward stiffer substrates via durotaxis, relying on focal adhesions. Here, the authors show that confined cells can migrate up friction gradients without focal adhesions, revea...
