Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure.
We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
A beautiful study from the Pausch lab!
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
My main postdoc paper repost marked as spam - just for the memories. Shame, shame @moderation.bsky.app! 😀
Petr Skopintsev
New online: Structure and mechanism of antiphage retron Eco2
Patrick Bryant
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to @isabelesain.bsky.social, @evandeturk.bsky.social, @doudna-lab.bsky.social, @jacobsenucla.bsky.social, @jhdcate.bsky.social, @banfieldlab.bsky.social, @innovativegenomics.bsky.social!
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social
Petr Skopintsev
Nature Structural & Molecular Biology, Published online: 18 February 2026; doi:10.1038/s41594-026-01754-2This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein production and stops phage replication.
Can we simulate realistic evolutionary trajectories and “replay the tape of life”? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n
doi.org/10.64898/202...
Nature Structural & Molecular Biology
Petr Skopintsev
doi.org
1/6) Hot off the press @natsmb.nature.com 🔥! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage 🛡️. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication 🦠🚫. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH
Phil Holliger
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Yun S. Song
Nature Structural & Molecular Biology - This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein...
Across all domains of life, immune systems rely on nucleotide-based signaling molecules
to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg,
and colleagues identify ...
