Happy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....
Are you in years 3-8 of an independent faculty position?
The Emerging Leader Award was built to give you the research runway you need. The award now offers $1M over 4 years and is open to investigators worldwide!🌎
Apply by April 30: themarkfoundation.org/emerging-lea...
#ResearchFunding
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...
New preprint out!
Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...
Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
www.biorxiv.org
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
We are recruiting a computational scientist for a postdoc position to work on detecting RNA modifications using nanopore sequencing:
tinyurl.com/RiboComp
Deadline March 4th.
Please share and repost!
More on the group: www.bric.ku.dk/research-gro...
Video
Marvin Tanenbaum
We are looking for a highly motivated and dynamic computational postdoc for a 3-year position to join the Lund Group. Our research Our team aims to understand htinyurl.com
www.science.org
Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains...
