Cancer researcher, RNA biologist, and all round science geek, based at the University of Bristol. Ribosomes FTW.
Liam Faller
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Happy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....
www.cell.com
We are recruiting a computational scientist for a postdoc position to work on detecting RNA modifications using nanopore sequencing:
tinyurl.com/RiboComp
Deadline March 4th.
Please share and repost!
More on the group: www.bric.ku.dk/research-gro...
David Suter
Human DHX29 detects nonoptimal codon usage to regulate mRNA stability | @science.org www.science.org/doi/10.1126/...
tinyurl.com
We are looking for a highly motivated and dynamic computational postdoc for a 3-year position to join the Lund Group. Our research Our team aims to understand h
Synonymous codon usage controls global gene expression in both prokaryotic and eukaryotic species. Nonoptimal codons are known to induce mRNA decay; however, the underlying molecular mechanism remains...
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Video
For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵
www.biorxiv.org/content/10.6...
There are Science papers and then there are *I just dropped and shattered my mug of coffee Usual Suspects style* Science papers www.science.org/doi/10.1126/...
Anders H. Lund
New preprint out!
Our latest work on how ZAKα is activated by stalled or/and collided ribosomes is now online🎉. #Ribosome #RibotoxicStressResponse #ZAKα #Translation #mRNA www.biorxiv.org/content/10.1...
Beckmann Lab
Vaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there??
#CellBiology #WTFology
www.biorxiv.org/content/10.6...
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA
www.science.org/doi/10.1126/...
co-first with: @andschwarz.bsky.social
with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more
🧵 0/6
#MolBio 🧪
Di Jiang
Are you in years 3-8 of an independent faculty position?
The Emerging Leader Award was built to give you the research runway you need. The award now offers $1M over 4 years and is open to investigators worldwide!🌎
Apply by April 30: themarkfoundation.org/emerging-lea...
#ResearchFunding
www.biorxiv.org
Video
Despite a growing interest in the ribotoxic stress response (RSR), it remains unknown how the upstream p38 and JNK-activating MAP3 kinase ZAKα senses translational impairment. Combining Alphafold3 pre...
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using ...
