📣New work on chalcogen bonding in collaboration with V. Yu. Kukushkin. We used Perfluoroaromatic Selenoxides! Nice Crystal Engineering results via Se···O/Se···N Chalcogen Bonding, and Theoretical Analysis @pubs.acs.org @dquimicauib.bsky.social @biblioteca.uib.cat pubs.acs.org/doi/abs/10.1...
Happy to share my last collaboration with J.J. Weigand and his group! @tudresden.bsky.social We reported convenient methodologies for P(V) to P(III) conversion and CO2/CS2 activation. Just published in @inorgchemfront.rsc.org @rsc.org. @dquimicauib.bsky.social @uib.cat
pubs.rsc.org/en/content/a...
📣Delighted to share my last collaboration with V. Yu. Kukushkin and K. A. Lotsman, just published in @pubs.acs.org. We report halogen-dependent switching between σ-Hole and π-Hole donor modes in halopolyfluorobiphenyl platforms. @dquimicauib.bsky.social @uib.cat 👏👇
pubs.acs.org/doi/full/10....
📣Proud of this collaboration with @duanechl.bsky.social and his group! We report new Norfloxacin–NSAID Pharmaceutical Salts and study their Structure–Property Relationships for Enhanced Solubility and Stability. @pubs.acs.org @dquimicauib.bsky.social @uib.cat 😀👇
pubs.acs.org/doi/full/10....
New collaboration with J. Weigand just published in @chemicalscience.rsc.org were we studied Imidazoliumyl-Substituted Di- and Iso-Tetraphosphanes and Their Metal-Mediated Fragmentation Reactions. @dquimicauib.bsky.social @uib.cat
pubs.rsc.org/en/Content/A...
📣Proud of this work in collaboration with analytical groups. We propose a methodology for controlling the quality of avapritinib drug just published in Scientific Reports. @dquimicauib.bsky.social @biblioteca.uib.cat
www.nature.com/articles/s41...
📣In this new manuscript we analyze cooperativity and anticooperativity effects in a cadmium-based MOFs. Interestingly, they show catalytic efficacy for the Knoevenagel condensation. Just published in Langmuir👇
@pubs.acs.org @dquimicauib.bsky.social @biblioteca.uib.cat
pubs.acs.org/doi/full/10....
New amazing work in collaboration with M. S. Wickleder and J. Langwald @unicologne.bsky.social just published in
@daltontrans.rsc.org The [Se4]2+ dication is shown to exhibit electrophilic duality, engaging in σ- and π-hole interactions. @dquimicauib.bsky.social @uib.cat 👇
doi.org/10.1039/D6DT...
Delighted to share our latest work on norfloxacin–NSAID pharmaceutical salts, revealing key insights into solubility, stability & hydration resistance.
First paper from Carol Belmont PhD thesis
Great collaboration with @tonifrontera.bsky.social &
F.J. Acebedo
doi.org/10.1021/acs....
📣😀Thrilled to share that my first collaboration with Prof. Lili Zong has been published in JACS!! @pubs.acs.org. We demonstrated that fluorinated pentanidium enables enantioselective desymmetrization of phosphinic acids. 👇@dquimicauib.bsky.social @biblioteca.uib.cat
pubs.acs.org/doi/full/10....
Duane Choquesillo-Lazarte
The use of antibiotics is usually associated with mucosal damage and antimicrobial resistance due to inefficient dosing. This issue is particularly relevant for norfloxacin (NOR), whose amphoteric nat...
This study systematically investigates the halogen-dependent interplay between σ-hole (halogen bonding) and π-hole (perfluoroarene–arene stacking) interactions using a bifunctional perfluoroarene–aren...
Two polynuclear cadmium(II)-based metal−organic framework complexes, [CdL1bpy]n·nH2L1(1) (H2L1 = 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid, bpy = 4,4′-bipyridine) and [CdL2ClH2O]n(2) (H...
pubs.acs.org
The use of antibiotics is usually associated with mucosal damage and antimicrobial resistance due to inefficient dosing. This issue is particularly relevant for norfloxacin (NOR), whose amphoteric nature leads to strongly pH-dependent solubility and low oral bioavailability. To overcome these limitations, this work presents three novel drug–drug pharmaceutical salts of NOR with the anti-inflammatory drugs ketoprofen (KET), dexketoprofen (DKT), and niflumic acid (NIF). Salts were synthesized by mechanochemical and slurry strategies and fully characterized using thermal, spectroscopic, and X-ray diffraction techniques. The crystal structure, along with DFT and QTAIM computational analyses, showed that salts are governed by tetrameric assembly formation. However, while NOR–KET and NOR–DKT are stabilized by robust charge-assisted hydrogen bonds, NOR–NIF packing arrangement is dominated by weaker hydrogen bonds together with π–π and CF3···π interactions. These supramolecular differences were directly reflected in the pharmaceutical performance. The salts suppressed the rapid hydration of NOR under aqueous environments and showed improved stability at physiological pH. Moreover, NOR–KET and NOR–DKT significantly enhanced the solubility of both NOR and the corresponding NSAIDs in PBS at pH 6.8, while all salts provided a more controlled NOR dissolution profile under acidic conditions. These findings demonstrate that salt formation is an effective strategy to overcome the solubility and stability limitations in NOR and NSAIDs, offering a framework for improving the performance not only of NOR but also of other APIs facing similar challenges.
Chalcogen-bonded (ChB) synthons have become essential tools for crystal engineering and supramolecular chemistry. This work explores perfluoroarylselenoxide (Ar2FSe═O) moieties as a promising class of...
Catalyst design within chiral cationic phase-transfer catalysts (ccPTCs) has commonly relied on the assistance of hydrogen bonding and steric hindrance to achieve high stereochemical control. In contr...
