"... y entonces dice "adiĂłs"...
aliviada de su tristeza que durĂł medio siglo;
con su belleza de risa,
con perfume eterno de claveles en la palma de su mano...
Hora de descansar, ahora."
Taty Almeida (Lidia Stella Mercedes Miy Uranga)
1930 - 2026
La referente de Madres de Plaza de Mayo
Findings from #MacKinnonLab at @rockefeller.edu:
bit.ly/4gg9l4t
" ... and then she says "goodbye"...
relieved of her sadness that lasted half a century;
with her beauty of laughter,
with the eternal perfume of carnations in the palm of her hand...
Time to rest, now."
Taty Almeida (Lidia Stella)
1930 - 2026
The leader of the Mothers of the Plaza de Mayo
Dengue virus infection in Aedes aegypti mosquito brains elicits minimal transcriptional response bioRxivpreprint
dlvr.it
Billions of people each year are at risk from infection by dengue, Zika, yellow fever, and chikungunya viruses, which are transmitted by female Aedes aegypti mosquitoes. Mosquitoes themselves are infected by these arboviruses, but how the mosquito nervous system responds to arboviral infection is unknown. We combined whole-mount immunofluorescence with single-head bulk RNA-sequencing to characterize dengue virus (DENV) infection in the brain of Aedes aegypti. DENV productively infects brain cells in a bimodal pattern: individual brains showed either sparse or widespread infection, with no intermediate phenotypes. An infectious blood meal altered thousands of genes, including 64 immunity genes, at 7 days post-feeding (DPF), yet active viral replication in the head did not increase the transcriptional response. Heads with and without detectable DENV showed minimal transcriptional differences, with no induction of canonical immune effectors. Despite productive infection, the mosquito brain tolerates DENV replication with minimal transcriptional response.
How does the early life microbiota protect the infant against excessive adiposity? Our new preprint describes a mechanism by which specific members of the early life small intestine microbiota regulate intestinal epithelium-immune interactions to prevent adiposity.
www.biorxiv.org/content/10.6...
Perturbation to the early-life microbiota has long-term detrimental effects on health and development, leading to increased risk for metabolic dysfunction and childhood obesity. Despite the central ro...
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We're grateful to the 39 House members who are calling on HHS Secretary Kennedy to provide answers about #NIH grants management staffing shortages that have cut new grant awards roughly in half.
Full letter: drive.google.com/file/d/1Ls3E...
Researchers cannot afford these delays — and neither can those whose health and well-being depend on this #science. We look forward to the Secretary’s timely response.
Association for Psychological Science
Piezo1 under mechanical force adopts a unique conformation that depends on lipid membrane composition.
