This is very cool: a simple statistical test of dysbiosis, or really any microbiome composition data relative to a reference. Outperforms Bray-Curtis and every other metric, while simultaneously being very simple to compute. Probably would work on RNAseq data too.
Michael Baym
Ratio Percentile Deviation (RPD): A nonparametric, compositionally robust method for measuring the divergence of a microbial sample from a reference dataset https://www.biorxiv.org/content/10.64898/2026.05.27.728224v1
