A study led by VAI’s @rothbartlab.bsky.social and his team sheds light on how interwoven epigenetic layers work together to sustain cancer cell survival. Their findings reveal a potential weak spot that could be leveraged to improve treatment.
So excited to share our new paper working w/ David Lyden, Han Kim & Jackie Bromberg (WCM), led by the amazing Inbal Wortzel & Ifé Akano where we revealed a new & unexpected function for chromatin on the surface of exosomes in #cancer #metastasis @ Nature Cancer!
www.nature.com/articles/s43...
Are you a postdoc or PhD student interested in Histone and DNA modifications? Join us for the GRS on Histone and DNA Modifications!
🗓 When: July 19-20, 2025
📍 Where: Lucca, Italy
A great opportunity to present your work, engage in discussions, and network with peers.
🔗 Register now!
Register here
I am excited to announce that after a decade of service to the U of Florida during which the @ufhealthcancer.bsky.social received NCI designation, in January 2026 I will be assuming the role of President and Chief Scientific Officer of the @vai.org.
www.vai.org/article/emin...
Yael David
Van Andel Institute (VAI)
Short’s was Michigan’s best microbrewery even before this genius holiday marketing campaign! #bringmebacksomethingfrench
Happy holidays from our lab family to you and yours!
Anna Knörlein
We are proud of Yanqing and this outstanding accomplishment in recognition of her success and future potential!
Award and abstract submissions due April 20! Join FASEB for #BioMethylSRC! Featuring speakers @garcialabms.bsky.social and @metorrespadilla.bsky.social alongside organizers @brianstrahl.bsky.social, @vanrechemlab.bsky.social, @bonalditiziana.bsky.social, and @rothbartlab.bsky.social. buff.ly/3GCABMr
Jonathan D. Licht, M.D.
Thrilled to share a new study from the lab revealing an H3K18ub-H3K9me3 crosstalk mechanism, roles for UHRF1 and its E3 ligase activity in regulating a hierarchy of repressive histone methylation signaling, and a strategy for targeting SUV39H1/H2 to improve DNMT1 inhibitor efficacy! #epigenetics
Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social
Scott Rothbart
Scott Rothbart
Scott Rothbart
Scott Rothbart
Scott Rothbart
Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that ar...
Read about Pinpointing weaknesses in cancer’s armor on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
Liu et al. report that DNMT1 inhibition causes transient accumulation of hemi-methylated
DNA at CpG islands, which stimulates UHRF1-mediated H3K18ub. This enhances SUV39H1/H2
activity, nucleates new H...
VAI Graduate Student Yanqing Liu works to outsmart cancer by exploring the molecular tricks cancer cells use to survive. She recently received a prestigious award to support her research and contribute to the development of improved therapies. www.vai.org/article/figh...
Van Andel Institute (VAI)
Read about Fighting to outsmart cancer: A Q&A with graduate student Yanqing Liu on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.
