Original paper: www.sciencedirect.com/science/arti...
Thanks Leo for sharing! 🙏
In the midst of bad news in the word, it was amazing and humbling to see our recent discovery of sildenafil in Leigh syndrome in @cp-cell.bsky.social highlighted among five inspiring uplifting stories in @nature.com
www.nature.com/articles/d41...
Our spotlight article is out in Cell Metabolism highlighting the exciting publication by Du et al in Cell showing the effectiveness of mitochondrial transplantation @cellpress.bsky.social
authors.elsevier.com/a/1n2ge5WXUl...
In this new review Wittich et al., including @aleprigio.bsky.social, discuss human stem cell–derived #organoids as increasingly powerful 3D models for #drugdiscovery, improving disease modeling & drug screening by better capturing human tissue structure & function.
🧪 #NAMs #biotech
Super excited to share our latest work! In collaboration with Antonio del Sol, we show that brain organoids coupled with deep learning screening allow uncovering new repurposable drugs for the incurable mitochondrial disease Leigh syndrome.
www.nature.com/articles/s41...
Species recovery, cancer-preventing vaccines and progress in developing renewable-energy sources are just some of the positive developments that have happened this year so far.
Mitochondrial transplantation holds significant potential for the treatment of mitochondrial diseases. However, how to efficiently deliver exogenous m…
Leigh syndrome is a severe, currently untreatable mitochondrial neurological disorder. Menacho, Okawa et al. developed a deep-learning drug screening pipeline in brain organoids, identifying azole com...
www.nature.com/articles/s41...
Check this from @aleprigio.bsky.social
Thank you very much @mitoworld.bsky.social for highlighting our work and the upcoming trial!
We plan to start recruiting individuals with MT-ATP6 variants later this year.
Brain organoids used to screen drug candidates for genetic mitochondrial disease Leigh Syndrome identifies utility of sildenafil (Viagra)
📷 Annika Zink, Dao-Fu Dai, Annika Wittich et al @aleprigio.bsky.social
@hhu.de in @cp-cell.bsky.social
➡️ bpod.org.uk/archive/2026... +
@rooph.bsky.social
Leigh syndrome is a severe, currently untreatable mitochondrial neurological disorder. Menacho, Okawa et al. developed a deep-learning drug screening pipeline in brain organoids, identifying azole com...
A patient‑derived iPSC screen by Prigione identified sildenafil as a potential therapy for #LeighSyndrome, a devastating #mitochondrialdisease. @cp-cell.bsky.social
Now recruiting for clinical trials!
mitoworld.org/using-ips-ce...
#UMDF #mitoscientists #mitochondria #SynLeigh
@ema.europa.eu
A patient‑derived iPSC screen by Prigione identified sildenafil as a potential therapy for #LeighSyndrome, a devastating #mitochondrialdisease. @cp-cell.bsky.social
Now recruiting for clinical trials!
mitoworld.org/using-ips-ce...
#UMDF #mitoscientists #mitochondria #SynLeigh
@ema.europa.eu
mitoworld.org
A screen of iPS cells recently identified sildenafil as a potential treatment for Leigh syndrome (LS). Moreover, further testing of the drug showed marked improvement in animal models and human patien...
A screen of iPS cells recently identified sildenafil as a potential treatment for Leigh syndrome (LS). Moreover, further testing of the drug showed marked improvement in animal models and human patien...
Fantastic work from @andrearossilab.bsky.social Rossi lab on the development of @cleanfinder.bsky.social for nuclear and mitochondrial genome editing application. Greatful that my lab have contributed!
www.MitoWorld.org
www.MitoWorld.org
Alessandro Prigione
Excited to share that our work on CleanFinder is published in Trends in Biotechnology! 🎉
Analyzing complex allele mixtures across editing modalities and sequencing platforms is a major bottleneck. We developed CleanFinder to solve this.
Read it here: www.sciencedirect.com/science/arti...
Genome editing often generates complex mixtures of alleles rather than single, predefined outcomes. Resolving these heterogeneous edits across diverse…
