Friends, I'm pleased to draw your attention to two new preprints today describing complementary heteroatom insertion reactions into saturated carbocycles, one from our group and another from the Knowles laboratory.
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Congratulations to Yoon Lab PhD #26, Dr. Tahoe Fiala!
Our two other finalists were the Jacobson group's catalysis of an Sn2 by geometric preorganization (doi.org/10.1038/s41586-024-07811-4) (the mod's personal favorite) and the Reisman/Peters groups' report on catalytic Sm (doi.org/10.1126/science.adp5777)
On Monday we held our annual paper of the year group meeting, and the group has selected the Macmillan group's alcohol-alcohol cross coupling enabled by SH2 radical sorting as our favorite paper of 2024! (doi.org/10.1126/science.adl5890)
Two other papers that garnered a lot of discussion in our PoY process were the Park group's report on photocatalytic furan to pyrrole conversion (doi.org/10.1126/science.adq6245) and the Phipps group's report on enantioselective HAA to epimerize of meso diols (doi.org/10.1126/science.adq8029)
Really excited to see this amazing work out in ChemRxiv from our #ChemCollab between the @uwyoongroup.bsky.social @tehshik.bsky.social and #PfizerChemistry
Photochem-mediated oxygen migration into sp3 bonds delivering small ring ethers as well as an OH - methylene transposition
#ChemSky 1/
We're thrilled to welcome new first years Jenna Krussman and Maia Carvalho to the group!
Exo-to-endo nitrogen transposition in saturated rings
Authors: Danny Thach, Robert Knowles
DOI: 10.26434/chemrxiv-2025-nlj7m
also see this great exo-to-endo nitrogen transposition in saturated rings by the Knowles lab! chemrxiv.org/engage/chemr...
Tehshik Yoon
Yoon Group
Yoon Group
Yoon Group
Yoon Group
Yoon Group
A small-molecule (646 Da) hydrogen-bond-donor catalyst accelerates the SN2 step of an enantioselective Michaelis–Arbuzov reaction by recapitulating the geometric preorganization principle used by enzy...
The identity of a heteroatom within an aromatic ring influences the chemical properties of that heterocyclic compound. Systematically evaluating the effect of a single atom, however, poses synthetic c...
