🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeri...
