🎉 New paper out in Science!
In collaboration with Marc Therrien’s lab, we show how oncogenic BRAF mutants adopt a pre-active conformation, escaping auto-inhibition and driving RAS–ERK pathway activation in cancer.
Proud to have contributed! #IRIC #CBMN @iecb.bsky.social @univbordeaux.bsky.social
🚨 Fully funded PhD position in plant & structural biology! Join the @eliastahl.bsky.social lab in collaboration with our team. Exciting project on protein structure/function in plants 🌱. Contact us for details!
#PlantBiology #StructuralBiology #PhDposition @iecb.bsky.social
Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeri...
Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
Video
PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com
🔬 Braf : le verrou moléculaire que les cellules cancéreuses peuvent forcer - Une équipe internationale, dont des scientifiques bordelais du CBMN*, explorent une piste prometteuse pour entraver ces cellules cancéreuses :
Flying start to the #iubmbkinases meeting in beautiful Queenstown, NZ. Jubilee Award from IUBMB to Kevan Shokat yesterday, and a kinase masterclass from Susan Taylor this morning
With less than a month to submit abstracts for the
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
Jane Dudley
Dr. Natalia Riobo-Del Galdo
Oli Clarke
Des scientifiques ont percé le secret de mutations génétiques communes à de nombreux cancers qui activent de manière anarchique une protéine-clé de la d
We are recruiting!
A three year PhD position @iecb.bsky.social and @lbm-bordeaux.bsky.social to study lipid recognition by plant receptor-like kinases. A collaborative project with the team of @pierre-maisonneuve.bsky.social. Join us in the beautiful city of Bordeaux!
emploi.cnrs.fr/Offres/Docto...
New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation.
Learn more in this week's issue: scim.ag/44uRorm
Peter Mace
Université de Bordeaux
High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1
