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looking forward to reading this! Love to see an RRM-by-RRM dissection as similar principles are employed by so many multi-RBD proteins.

2mo

Irene Beusch

NAR breakthrough alert 🎉 Joint work with @mfeldbruegge.bsky.social on Rrm4. We dissect its modular RRM binding code & how domain combinations shape RNA interactions. Like finding needles in a haystack, comparative iCLIP sorts functional vs accessory sites. Work by Nina & @srimeenakshi.bsky.social

2mo

Zarnack Group

Breakthrough article 😊 Joint effort of teams Zarnack & König & Feldbrügge clarifies how multiple RNA-binding domains cooperate to identify functional important binding sites in vivo doi.org/10.1093/nar/... @zarnack-group.bsky.social @könig-lab.bsky.social @mibinet.bsky.social #EMBOrnaLocalization

2mo

Abstract. RNA-binding proteins (RBPs) utilize multiple RNA-binding domains (RBDs) to engage with extensive messenger RNA (mRNA) networks. Understanding the

doi.org

Dissecting the RNA-binding capacity of the multi-RRM protein Rrm4 essential for endosomal mRNA transport

Michael Feldbrügge