Briefly, these vesicles segregate from synaptophysin-positive vesicles, resist canonical size constraints, and selectively recruit SV2C; features that may underlie dopaminergic vulnerability in Parkinson’s disease.
Please join me for the upcoming talk in the neurocolloquium!
At ASCB this year in Philly? Will speak about MT lattice spacing in cells and neurons 🙂 See info below..
Nisha Rafiq
Looking forward to sharing our work here!
What distinguishes dopamine vesicles from other synaptic vesicles?
Our new preprint addresses this question: www.biorxiv.org/content/10.6...
Huge shoutout to @Kenshiro Fujise for the stunning EM images! 🎉
For broader context, see our Trends review last year on what this means for the field: www.sciencedirect.com/science/arti...
Listened to the talk by the first author at SfN and was pleasantly surprised to see so many synaptic proteins, including my all-time favorite: synaptojanin-1!
Nisha Rafiq
Nisha Rafiq
Nisha Rafiq
🧪⚛️ Surface tension—driven by non-equilibrium currents not forces—in pattern formation leads to the same type of interface laws as in liquid foams: Plateau laws, von Neumann evolution; and a new emergent phenomenon: domain splitting akin to cell division. nature.com/articles/s4156…
Nisha Rafiq
How do cells recognize matrix topography? In this preprint we show that α5β1-integrin fibrillar adhesions rapidly form in response to topographic cues like electrospun nanofibers- no actomyosin contractility, focal adhesions or fibronectin secretion needed
doi.org/10.1101/2025...
Nisha Rafiq
Nisha Rafiq
Preprint 🧵!
I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition!
BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a
www.biorxiv.org/content/10.6... (1/6)
