This project builds on work establishing the behaviour done at Champalimaud in Lisbon with @michaelfsp.bsky.social, Beatriz Godinho, Christian Machens, and @ruimcosta.bsky.social : www.biorxiv.org/content/10.6...
Action selection using predictive models of the environment plays a fundamental role in human and animal behaviour, yet is poorly understood at circuit and algorithmic levels. Spatial navigation is an...
It has been super fun to work on this, where we learned that:
1) Mouse PFC is needed for model-based override of habits.
2) Separate PFC populations encode a 'policy' and the current 'value'.
3) The policy and value codes alternate theta sweeps towards the goal.
...and much much more!
Kris Jensen
How do brains plan actions towards goals?
To get at this question we studied mice navigating complex mazes as goals changed on every trial 🧵
Work with @thomasakam.bsky.social @behrenstimb.bsky.social @kristorpjensen.bsky.social now on BioRxiv: www.biorxiv.org/content/10.6...
