Assistant Professor of Biochemistry and Biophysics, University of Pennsylvania
https://www.yiweichanglab.org/
Structural biology; cryo-electron tomography; host-pathogen interactions
Yi-Wei Chang
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
Video
Congratulations to Melanie Ohi for this very well-deserved recognition!
Thrilled to share that our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller, now is formally published! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
Yi-Wei Chang
Exciting update on the CryoET Data Portal! A new annotation set from Mart Last & team is now live. They’ve doubled available annotations with >1,800 tomograms of Chlamydomonas reinhardtii which now have almost fully dense labels, and all can be visualized in the browser using Neuroglancer.
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
authors.elsevier.com
🦟🌍 Join us for the 21st edition of #EMBLMalaria as we strengthen partnerships, share insights, and drive innovations to combat malaria's toll and advance global health.
📅 20 – 22 May 2025
📍 EMBL Heidelberg and Virtual
📝 Submit abstract by 25 Feb
👉🏻 s.embl.org/bmp25-01-bl
#malaria #epidemiology
Yi-Wei Chang
Yi-Wei Chang
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
As 2026 chair of the Biophysical Society Cryo-EM subgroup, I am thrilled to announce that Dr. Melanie Ohi has been selected as the recipient of the June Almeida Award: an honor recognizing women scientists whose leadership, scholarship, and mentorship have profoundly shaped the field of cryo-EM.
