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🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
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How does RNA know where to go in the nucleus?
In a preprint in collaboration with Jingyi Fei's lab, we uncover the sequence logic that drives RNA localization to nuclear speckles—and its tight coupling to splicing.
đź”— [https://doi.org/10.1101/2025.05.28.656493]
#RNA #splicing