🚨 Postdoc opening in the Regev Lab at NYU
We are hiring wet-lab postdocs to join our efforts to uncover RNA biology with interpretable ML and develop novel RNA therapeutic approaches using synthetic biology and high-throughput assays.
Reposts appreciated!
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⏱️ We find that speckle localization correlates with splicing kinetics.
Stronger localization → Faster splicing
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🧠 Altogether, we propose a model:
RNA speckle localization = a marker of early spliceosome assembly, helping ensure efficient and accurate splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
This project was led by Li Wen (@UChicago) and Mauricio A. Arias (@NYU_Courant).
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How does RNA know where to go in the nucleus?
In a preprint in collaboration with Jingyi Fei's lab, we uncover the sequence logic that drives RNA localization to nuclear speckles—and its tight coupling to splicing.
🔗 [https://doi.org/10.1101/2025.05.28.656493]
#RNA #splicing
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🧬 Disease-associated single nucleotide variants (SNVs) reduce the localization of isolated exons, hinting at a potential mechanism for splicing-related pathologies.
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🔍 Nuclear speckles are membraneless organelles involved in RNA processing.
But what determines which RNAs localize to speckles?
We found that pre-mRNA-like sequences—even in unspliceable transcripts—drive localization.
