Structural biologists | Associate professor at the University of Copenhagen | EMBL-Hamburg, DANDRITE AU, and MolBiolAU Alumni.
Azadeh Shahsavar
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Many thanks to the @novo-nordisk.bsky.social for highlighting our GlyT2 story!
#CryoEM
sciencenews.dk/en/a-pain-dr...
🚨My new team at @ipbstoulouse.bsky.social in France currently have an open, fully-funded PhD position 🧑🔬👩🔬to study membrane proteins & transporters of therapeutic interest using cryo-EM & biophysics.🧊🔬🦠
#StructuralBiology #MicroSky
Please share 🤝
For more details 👇
Pedersen, C. N., Yang, F., Ita, S., ..., Mortensen, O. V., Nissen, P., Shahsavar, A. (2024). Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J Neurochem, onlinelibrary.wiley.com/doi/10.1111/...
Our findings provide proof-of-concept for the rational design of GlyT2 inhibitors and a clear avenue for novel treatments of chronic neuropathic pain.
This interdisciplinary research represents nothing less than a tour de force by Ryan P. Cantwell Chater, and a great collaborative effort between the labs of
Robert Vandenberg, Christopher Cioffi, Megan O'mara, Mike Michaelides, Sarasa Mohammadi and myself.
We are grateful for the support from:
@lundbeckfonden.bsky.social
@novo-nordisk.bsky.social
@ NIDA
