We study molecular mechanisms of ageing and adaptation.
Babraham Institute, Cambridge, UK. Main funding BBSRC, Wellcome
Views are our own.
Houseley Lab
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6-way multiplexing at the first step allows 10-20 libraries to be made in parallel
Great work Neesha and thanks to our collaborators and our funders
TrAEL-seq read density reflects the speed or replication forks, allowing quantification of interactions with genomic elements such as transcription
TrAEL-seq profiles rival quality to OK-seq but are much easier to generate
Houseley Lab
Need to profile DNA replication genome-wide?
TrAEL-seq reveals replication patterns and fork progression in unsynchronised, unlabelled and unsorted cells
Our revised protocol:
• Provides far better data from mammalian cells
• Includes 6-way multiplexing
academic.oup.com/nar/article/...
Exciting new project in our lab @babrahaminst.bsky.social! We are working with @alesdantas.bsky.social at @newcastleuni.bsky.social to understand how extrachromosomal circular DNA mediates drug resistance in fungal pathogens
Funded by @wellcometrust.bsky.social
#ecDNA #eccDNA #Candida #Zymoseptoria
Houseley Lab
Travel Grants for #BSRA2026!!!
Don't forget there is a seperate travel grant call *just* for BSRA 2026, our 75th annual meeting. This year in Oxford, it's promising to be a great meeting.
bsra.org.uk/grants/
Like and share, or tag someone who should apply below👇
Houseley Lab
Houseley Lab
Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7)
www.cell.com/cell/fulltex...
Houseley Lab
Latest paper. We studied ATF4 in ageing in the fly. We find in contrast to previous suggestions that ATF4 suppression rather than activation extends lifespan.
The study was largely conducted in an MSc project by Miriam Götz who showed an exceptional drive for science.
www.pnas.org/doi/10.1073/...
Tardigrades resist heavy DNA damage by actively repairing such lesions & expressing DNA-protective proteins. Yet, they are not immortal. How & why do they die? @morielab.bsky.social now shows that their Achilles' heel is DNA replication: duplicating your DNA... will kill you doi.org/10.1111/febs...
Peter Ly
The UK is one of only five of the richest 21 countries to see HLE decline. @ONS reports that healthy life expectancy is falling.
BSRA advocates for increased funding in ageing research so we can all live healthier for longer.
Dataset in the comments 👇
www.bbc.co.uk/news/article...
Mirre Simons
@MorieLAB
British Society for Research on Ageing
British Society for Research on Ageing
bsra.org.uk
Grants We are pleased to announce an additional grant call for 2026, for Travel Grants to attend our 75th ASM in Oxford from 9-11 September. CALL NOW OPEN. Closing date 1st May 2026. More details here...
DNA damage in the tardigrade Hypsibius exemplaris elicits distinct cellular outcomes depending on replication status. While non-replicating cells tolerate genotoxic stress, constitutively replicating...
doi.org
Poor housing, obesity and the effects of deprivation have been suggested as underlying cause.
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
