Mini-reunion of @costalaboratory.bsky.social from the 2020/21 era. Had a great time at the 94th Harden Conference in Crete, reconnecting with old colleagues and making new connections. Looking forward to the next one! @biochemsoc.bsky.social @tcr-miller.bsky.social @puehringertom.bsky.social
Glad to have presented my postdoctoral work from the @voslab.org lab in the last machines on genes conference. Thank you to the organizers and to the @biochemsoc.bsky.social for the opportunity and for bringing us to beautiful Crete.
#Biochemevents
The full story can be read here: biorxiv.org/content/10.64898/2026.05.15.725318v1.full.pdf 3/3
Two Mcm10 molecules brace two converging CMGs, enabling them to pull duplex DNA apart and establish divergent replication forks. @giacomopalm.bsky.social 2/3
New preprint! How does Mcm10 promote the establishment of two divergent replication forks from one MCM double hexamer? Our @giacomopalm.bsky.social found the answer. 🧵 1/3
Lead author @puehringertom.bsky.social made a key discovery: Sld2 has an essential role in establishing the replication fork, acting after CMG is assembled. Biochemical reconstitution + cryo-EM. 2/3
New preprint from our lab! We've been working out how the CMG replicative helicase gets built. 🧵 1/3
