Now peer reviewed and in its final form @natcomms.nature.com
www.nature.com/articles/s41...
The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...
Happy to share our latest work🍾 🥳
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Julian Stingele
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink
