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by @danabra.mov
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by @jimpick.com
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Happy to share our latest work🍾 🥳 PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Nov 28, 2024
Julian Stingele
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
Nov 28, 2024
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink
www.biorxiv.org
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
bioRxiv Biochemistry