Research group led by Claudine Kraft at the
@UniFreiburg
Our focus is on understanding the molecular mechanisms of #yeast and #mammalian #autophagy.
Profile run by Riccardo.
Claudine Kraft's Lab
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Congratulations to our SFB 1381 PIs Claudine Kraft and Carola Hunte and their teams - great story on the link between the mitochondrial fission and autophagy machinery!
A new preprint from the lab showing how Atg1 regulates the BLTP Atg2. This study was spearheaded by Sonja Achleitner and Susanna Tulli, involving a fantastic collaboration with @ainaraclaveras.bsky.social and Gerhard Hummer. @maxperutzlabs.ac.at @viennabiocenter.bsky.social @maxplanck.bsky.social
New pre-print from the lab! We show that the subtilase SBT12a is essential for symbiosome stabilization in Medicago. Using HUNTER proteomics, we even got some of its substrates. Have a look.
www.biorxiv.org/content/10.6...
We could show that MTFR1L was found at ULK1 foci, and its depletion impairs mitophagy flux and reduces cell survival under starvation. Clearly a protein worth watching. Interestingly, a concomitant PNAS study also highlights its role in cardiac aging and mitochondrial homeostasis in cardiomyocytes
SFB 1381 - Protein Machineries
Safe to say that Day 1 of 'Cellular mechanisms driven by phase separation' has been a success so far, with lots of great talks, including a keynote by Karla Neugebauer, and plenty of opportunities to socialise and get to know each other 🙌🏼 #EESPhaseSeparation @embo.org @embl.org
Our ULK1–MTFR1L paper is now officially in @jcellsci.bsky.social, a good moment to reshare it. 🎉
The work identifies MTFR1L as a key coordinator of mitochondrial fission, mitophagy initiation and apoptosis.
👉 Paper: doi.org/10.1242/jcs....
And JCS published a First Person interview with Riccardo, Leon, and Chris, worth a read if you're curious about the story behind the science:
👉 journals.biologists.com/jcs/article/...
Two of our lab members are at the EMBO | EMBL Symposium on cellular mechanisms driven by phase separation this week! 🙌
Come and visit their posters:
📌 Mariya → Poster #114
📌 Joachim → Poster #54
#EESPhaseSeparation @events.embl.org @embo.org @embl.org
🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery.
🔗Find the paper here: doi.org/10.1242/jcs....
🚨 Paper Alert! In this new work published in @jcellsci.bsky.social we shift our focus on MTFR1L and the feedback loop linking mitochondrial fission, mitophagy and apoptosis. MTFR1L emerges as a critical coordinator of the fission and autophagy machinery.
🔗Find the paper here: doi.org/10.1242/jcs....
Sascha Martens
New preprint! Cell division has to happen at the right place but how Archaea pick that place is unknown. We now identified a three-protein system, Dip, that positions the divisome at midcell in H. volcanii and is broadly conserved across Archaea. A thread 🧵
www.biorxiv.org/content/10.6...
Claudine Kraft's Lab
Summary: MTFR1L acts at mitochondrial mitophagy initiation sites, linking mitochondrial fission with autophagy by interacting with ULK1, regulating ATG13 stability, and forming a feedback loop that su...
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Riccardo Bab...
