Deputy Director of the Institute for Intelligent Biotechnologies at HelmholtzMunich, former editor @naturebiotech.bsky.social, all views expressed here are my own
Markus Elsner
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What if we could predict cancer 5+ years ahead and prevent it? A new landmark study shows the way. Exciting!
erictopol.substack.com/p/a-new-path...
My brain feels really hyper-vascularized today. You need to read our pre-print to learn why this is not necessarily a good thing ...
Multispecific T-cell engagers attract cancer drug developers
nature.com/articles/d41...
Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors
What a week! My first Points of View was published
@natmethods.nature.com
Happy to start the series in 🏳️🌈 month with "On Color scales and the birth of Viridis" - looks good, allows naming of regions, AND is perceptually uniform
🎁 rdcu.be/fnPhk
www.nature.com/articles/s41...
#dataviz
Where do therapeutics go in the body?
SCP-Nano combines whole-body imaging and AI to map nanocarrier biodistribution at single-cell resolution, revealing both intended targets and unexpected off-target destinations.
Our recent work at @nature.com Biotechnology:
www.nature.com/articles/s41...
Today I’m excited to share our new study in Nature Biomedical Engineering, in which we used protein engineering to create a therapeutic able to completely eradicate metastatic ovarian cancer in mice. 🧵
www.nature.com/articles/s41...
A method for spatial CRISPR perturbation screening reveals how genetic changes alter coding and non-coding RNA in a native tissue context, including the tumor microenvironment #NBTNV www.nature.com/articles/s41...
rdcu.be/fotFb
An engineered ErbB oncogene-selective virus shows improved safety and efficacy for treating mouse models of ErbBr/HER2 positive ovarian cancer, showing promise for curing early cases and substantially...
LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform,
achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts.
Yang et al. demonstrate that chronic stress accelerates glioma growth by inducing bone-marrow-derived C5aR1+ stress-associated macrophages (SAMs) in tumor-bearing mice. Stress-induced sympathetic nerve activation induces ADRB2+ monocytes to become CD36+ lipid-laden SAMs. SAMs depletion suppresses stress-related glioma tumor growth, and SAM abundance correlates with self-reported stress levels and portended prognosis in patients.
A method for spatial CRISPR perturbation screening reveals how genetic changes alter coding and non-coding RNA in a native tissue context, including the tumor microenvironment.
Not all brains age the same🧐🧠
Using whole-brain 3D imaging combined with spatial proteomics, @erturklab.bsky.social revealed multiple trajectories of cerebrovascular aging.
A fascinating new study:
biorxiv.org/content/10.6...
I'm always excited to share great work from my colleagues! #Neuroscience
