Yang et al. demonstrate that chronic stress accelerates glioma growth by inducing bone-marrow-derived C5aR1+ stress-associated macrophages (SAMs) in tumor-bearing mice. Stress-induced sympathetic nerve activation induces ADRB2+ monocytes to become CD36+ lipid-laden SAMs. SAMs depletion suppresses stress-related glioma tumor growth, and SAM abundance correlates with self-reported stress levels and portended prognosis in patients.
