A #BriefReview summarizes data over the last 14 years on the immunopathogenic mechanisms underlying Pneumocystis pneumonia–related lung injury and examines the potential for targeting these pathways in adjunctive immune modulation therapy. Learn more: https://ow.ly/EwfG50Z1ctv.
In a #TopRead from Dr. Brian V. Geisbrecht, data show that Efb-C binding to C3b exerts additional inhibitory effects on the central complement components beyond blocking formation of the C3 proconvertase alone. Learn more: https://ow.ly/qzT150Z19xV.
AAI Councilor Dr. Maria-Luisa Alegre UChicago Committee on Immunology highlights how alloantigen biodistribution, presentation, and persistence influence the effectiveness of αCD154-based regimens and provides insights for improving graft survival and patient outcomes: https://ow.ly/A7Lc50Z19F3.
In this #TopRead article, data reveal an antitumor role of B cells in melanoma and demonstrate that their loss promotes tumor progression through reprogramming of the tumor immune microenvironment. Read about it in The JI: https://ow.ly/kR9Y50Z19Bj.
The Journal of Immunology
The Journal of Immunology
The Journal of Immunology
Downregulated miR-4492 can serve as a biomarker for the diagnosis and prognosis of community-acquired pneumonia as miR-4492 affects cell viability and the inflammatory response of human bronchial epithelial cells. Read more: https://ow.ly/mTN550Z198f.
Data in this #CuttingEdge article show how human macrophage identity is coupled to their site of residence for mucosal and lymphoid organs and is intrinsically maintained during activation and polarization. Learn more in The JI: https://ow.ly/1Qwi50Z19VA.
In a #CuttingEdge article, researchers developed a monoclonal antibody that targets CD5L:p40 but not its individual subunits and observed efficacy in reducing an antigen-dependent Th2 response and airway inflammation. Learn more: https://ow.ly/u7mK50Z19vJ.
New data reveal a novel metabolic regulatory role for Penaeus vannamei (PvHMC) in response to Vibrio parahaemolyticus infection, which suggests potential strategies for controlling acute hepatopancreatic necrosis disease in shrimp. Read more in The JI: https://ow.ly/QfBh50Z18Yb
This #BriefReview examines how the traditional separation between innate and adaptive immunity is being challenged by the adaptive-like characteristics observed in innate immune cells and the increasing evidence that T cells display innate-like features. Read more: https://ow.ly/A8Is50Z1co2.
New data establish hFc mice as a translational model for understanding echovirus adaptive immunity, defining the humoral response to infection, and identifying correlates of protection to guide future vaccine development. Learn more: https://ow.ly/r4rf50Z191A.
