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Computational biophysicist @ University of Würzburg (Germany) and @ Institut Pasteur (France). Machine Biophotonics Lab (Würzburg). Imaging and Modeling Unit (Paris). Translational imaging, deep learning for biology, drug discovery.

Christophe Zimmer

We have an open call for a group leader at the Rudolf Virchow Center for Integrative and Translational Bioimaging in Würzburg, Germany. Generous starting package, vibrant and highly interdisciplinary biomedical research environment. www.nature.com/naturecareer... Please spread the word.

Great collaboration with the lab of Edouard Bertrand, with important contributions from Benoît Lelandais, Marie-Cécile Robert, Michael Szalay, and Jean-Yves Tinevez. Thanks a lot to all. www.nature.com/articles/s41... (4/4)

Our data are consistent with constant binding rate, lifetime and extrusion speed of cohesin across different regions. This argues for a model where TAD dynamics is mainly governed by CTCF sites and opens the door to predictive simulations of DNA folding across the entire human genome. (3/4)

Tracking the 3D motion of loop anchors in multiple genomic regions, we confirm that TADs are highly dynamic. Our analyses indicate that TADs constantly fold into multiple extruding loops that bring anchors briefly together ~1x per hour, effectively shrinking their genomic distance by ~0.1 kb/s.(2/4)

Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)

If leading AI companies are indeed approaching the point of recursive self-improvement, a coordinated, verifiable, and universally applied pause is probably the only responsible solution to mitigate several major AI risks; at least until safety guarantees are developed and demonstrated. (1/2)

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

One week left to apply. Help us find new antimicrobials and understand the inner workings of bacteria – as a technical assistant in the Machine Biophotonics and Nanoscale Bacteriology labs at the Rudolf-Virchow-Zentrum, University of Würzburg – See details below (in German). Please spread the word.